Exploring Bioactive Compounds in Fruits for Depression Management: A Review of Mechanistic Insights and Nutritional Strategies

Abstract

Background: Depressions, a global health issue affecting over 322 million individual, imposes significant psychological and physiological burdens. Traditional antidepressants often yield insufficient results, highlighting the need for alternative approaches, such a dietary and herbal interventions. This review explores how fruits, vegetables, and specific herbs with anti-oxidants and anti-inflammatory properties may serve as preventive measure against depression.

Methodology: Relevant literature was reviewed, focusing on bioactive compounds in fruits, vegetables, and herbs that support neurotransmitter function and reduce oxidative stress and inflammation, key contributors to depression. Anti-oxidant rich compounds, such as polyphenols, vitamins, and minerals, were analyzed for their impact on neurotransmitters like serotonin, and dopamine, which are critical for mood regulation.

Results: Antioxidants and anti-inflammatory agents in these foods and herbs protect neuronal pathways, enhancing serotonin and dopamine availability. This action helps maintain neurotransmitter balance, which may alleviate depressive symptoms by countering the neurodegenerative effects associated with oxidative stress.

Conclusion: Incorporating anti-oxidants-rich herbs, fruits, and vegetables into the diet may complement traditional treatments for depression by targeting its underlying biological mechanism. Further interdisciplinary research is recommend to deepen our understating of these natural interventions and optimizes their use as preventive and complementary measures in mental health management.