Association of Total Cholesterol and Estrogen Receptor in Patients with Breast Cancer

Abstract

Objective: To determine the association of total cholesterol and Tumour Estrogen receptor in patient with breast cancer at tertiary care Hospital.

Material and methods: This cross-sectional study was conducted at the Department of Biochemistry and Diagnostic and Research Centre, Liaquat University of Medical & Health Sciences Jamshoro from February 2021 to August 2021.  All the female patients with biopsy proven diagnosis of breast cancer and those patients with no prior history of any other comorbidities were included. 5 ml venous blood sample fasting was collected from the cuboidal vein of each patient as was sent to diagnostic laboratory for analysis of total Cholesterol (TC), serum estrogen level, tumour estrogen receptor. All the data was recorded on study Performa. All the data was entered into the SPSS 20.0 version.

Results: A total of 56 patients were studied; their mean age was 46.51+8.29 years and mean duration of breast cancer was 6.10+4.34 months. Majority of the patients 44.6% were obese and 26.8% were overweight, while normal weight patients were 26.8%. However, one patient was underweight. Mean total cholesterol was 110.72+40.18 mg/dl. Mean serum estrogen was 29.49+46.35 and mean tumour receptors were 1.50+0.50. Tumour estrogen receptors was positive in 50.0% of the cases.  Although statistically insignificant (p = 0.440), the average total cholesterol in patients with positive tumour oestrogen was high.

Conclusion: Obesity was commonly seen in patients with breast cancer, according to the findings of this study. Obesity has an impact on the development and recurrence of breast cancer. Obesity, inflammation, and the tumour microenvironment all work together to promote tumor development in patients.